Bone diseases Group

The Bone diseases group has the following complementary key objectives:

• Fundamental research to identify cellular and molecular mechanisms that underlie bone and joint diseases.

• Population genomics to refine risk assessment through molecular characterisation.

• Erasmus MC Bone Center1 to enable healthcare providers to make more informed decisions and deliver tailored treatments and prevention strategies that are better suited to the individual genetic profiles of patients.

The aims related to fundamental research are to understand the cellular and molecular mechanisms that underlie bone regeneration, to understand the interplay of bone metastases with bone metabolism and to identify molecular mechanisms that underlie rare bone and mineral metabolism diseases. The specific aims related to population genomics include genomics-assisted medical decision-making, integration of genomic

discoveries across population-based and clinical studies, utilisation of genomics to unravel disease mechanisms and innovative use of analytical methods and -omics databases. The group’s work related to the Erasmus MC Bone Center sets out to unravel the genetic and non-genetic background of rare and complex disorders, to develop novel biomarkers and diagnostic tools and to test novel treatments through

clinical trials.

The combined objectives of the Bone diseases research group enable a unique translational approach towards the understanding and treatment of both common and rare bone and joint diseases.

Members

• Head of laboratory:  Bram van der Eerden

Principal Investigators:

* Bram van der Eerden

* Fernando Rivadeneira

* Evert van Velsen

* Marjolein van Driel

* Jeroen van de Peppel

* Carolina Medina-Gomez

* Katarina Trajanoska

Postdocs:

* Kirsty Huininga 

PhD students:

* Samuel Ghatan

* Tarsila de Moura Figueiredo

* Vid Pratelij

* Jiawei Li

* Xinpeng He

* Siwen Li

* Li Chen

* Nina Gerrekens

* Haojie Lu

* Yudong Zhao

* Siyuan Ruan

* Kai Hu

* Filipa Madancos Duarte

* Max Gijsbertsen

* Yuan Guo

* Zografia Zervou

* Mengyuan Cai

* Rebeca Hernandez Hernandez

* Sybren van Hal

* Rana Mabrouk

Technicians

* Marijke Koedam

* Iris van den Berge

* Jasmijn Erpelinck

Master students

Bachelor students